Important Safety Information about depo-subQ provera 104 you should know
depo-subQ provera 104 is a drug for birth control. It is also indicated for management of endometriosis-associated pain.
IMPORTANT SAFETY INFORMATION
Using depo-subQ provera 104 may cause you to lose calcium stored in your bones.
The longer you use depo-subQ provera 104, the more calcium you are likely to lose. The lost calcium may not return completely once you stop using depo-subQ
provera 104.
Loss of calcium may cause weak, porous bones (osteoporosis) that could increase the risk that your bones might break, especially after menopause. It is not known whether your risk of developing osteoporosis may be greater if you are a teenager when you start to use depo-subQ provera 104.
You should use depo-subQ provera 104 long-term (for example, more than 2 years) only if other methods of birth control are not right for you.
depo-subQ provera 104 does not protect you from HIV (AIDS) and other diseases spread through sex (STDs).
Who should not receive depo-subQ provera 104?
You should not receive depo-subQ provera 104 injections if you:
- Are pregnant or might be pregnant
- Have any unexplained vaginal bleeding
- Have or have ever had breast cancer
- Have ever had serious blood clots
- Have liver disease
- Are allergic to anything in depo-subQ provera 104
See the list of ingredients in depo-subQ provera 104
Possible side effects
Treatment may lead to loss of calcium from your bones. There are other major risks. They include abnormal or very heavy bleeding, liver problems, and allergic reactions such as hives, problems breathing, or not feeling right after the shot.
If you have any of the following symptoms, you may have a serious blood clot:
- Sharp chest pain
- Coughing blood
- Sudden trouble breathing
- Sudden severe headache with vomiting
- Blindness, trouble talking
- Weakness
- Numbness in an arm or leg
- Dizziness or feeling faint
- Swelling or severe pain in your leg
If you have any of these symptoms, you should call your healthcare provider right away.
Most common side effects
The most common side effects with depo-subQ provera 104 are:
- Changes in your monthly period
- Weight gain of a mean of 3 to 4 pounds during the first year
- A skin reaction where you got the shot
- Headache
Important things to remember
- depo-subQ provera 104 does not protect you from HIV (AIDS) and other diseases spread through sex (STDs)
- If you wait more than 14 weeks between shots, you could become pregnant. Therefore, it is very important to keep getting depo-subQ provera 104 every 3 months
- Many women stop having periods altogether within 1 year; but your period will come back eventually after you stop using depo-subQ provera 104
This is some of the most important information to know about depo-subQ provera 104. For more information, please click here for full Prescribing Information.
INDICATION
depo-subQ provera 104® (medroxyprogesterone acetate injectable suspension 104 mg/0.65 mL) is a drug for birth control. It also helps relieve pain related to endometriosis.
IMPORTANT SAFETY INFORMATION
Using depo-subQ provera 104 may cause you to lose calcium stored in your bones.
The longer you use depo-subQ provera 104, the more calcium you are likely to lose. The lost calcium may not return completely once you stop using depo-subQ
provera 104.
Loss of calcium may cause weak, porous bones (osteoporosis) that could increase the risk that your bones might break, especially after menopause. It is not known whether your risk of developing osteoporosis may be greater if you are a teenager when you start to use depo-subQ provera 104.
You should use depo-subQ provera 104 long-term (for example, more than 2 years) only if other methods of birth control are not right for you.
depo-subQ provera 104 does not protect you from HIV (AIDS) and other diseases spread through sex (STDs).
Do not take depo-subQ provera 104 if you are pregnant or might be pregnant, if you have any unexplained vaginal bleeding, have ever had breast cancer, have ever had serious blood clots, such as blood clots in your legs, lungs, heart, or head, have liver disease, or are allergic to anything in depo-subQ provera 104.
In addition to loss of calcium from your bones, other serious risks include abnormal or very heavy bleeding, liver problems, and allergic reactions such as hives, problems breathing, or not feeling right after the shot. If you have sharp chest pain, cough blood, suddenly have trouble breathing, have a sudden severe headache with vomiting, blindness, trouble talking, weakness, numbness in an arm or leg, get dizzy or faint, or have swelling or severe pain in your leg, you may have a serious blood clot and should call your healthcare provider immediately.
The most common side effects with depo-subQ provera 104 are changes in your monthly period, weight gain of an average of 3 to 4 pounds during the first year, a skin reaction where you got the shot, and headache.
Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
For Patient Information for depo-subQ provera 104, click here.
For Full Prescribing Information for depo-subQ provera 104, click here.

