How depo-subQ provera 104 works as birth control
depo-subQ provera 104 stops monthly ovulation
Every month one of your ovaries releases an egg. depo-subQ provera 104 prevents the release of this egg. This way, there is no egg for sperm to fertilize. This means your chances of getting pregnant are very low.
Over half of women stop having periods altogether
At the same time that depo-subQ provera 104 stops ovulation, it also causes a thinning of the endometrial lining. The shedding of this lining is called menstruation. This is also known as a woman’s “period.” When the lining is thin, there is nothing to shed. This is why over half of women may stop having periods altogether on depo-subQ provera 104. When women no longer receive depo-subQ provera 104 injections, their periods eventually come back. The thinning of the endometrial lining is another way that depo-subQ provera 104 prevents pregnancy.
INDICATION
depo-subQ provera 104® (medroxyprogesterone acetate injectable suspension 104 mg/0.65 mL) is a drug for birth control. It also helps relieve pain related to endometriosis.
IMPORTANT SAFETY INFORMATION
Using depo-subQ provera 104 may cause you to lose calcium stored in your bones.
The longer you use depo-subQ provera 104, the more calcium you are likely to lose. The lost calcium may not return completely once you stop using depo-subQ
provera 104.
Loss of calcium may cause weak, porous bones (osteoporosis) that could increase the risk that your bones might break, especially after menopause. It is not known whether your risk of developing osteoporosis may be greater if you are a teenager when you start to use depo-subQ provera 104.
You should use depo-subQ provera 104 long-term (for example, more than 2 years) only if other methods of birth control are not right for you.
depo-subQ provera 104 does not protect you from HIV (AIDS) and other diseases spread through sex (STDs).
Do not take depo-subQ provera 104 if you are pregnant or might be pregnant, if you have any unexplained vaginal bleeding, have ever had breast cancer, have ever had serious blood clots, such as blood clots in your legs, lungs, heart, or head, have liver disease, or are allergic to anything in depo-subQ provera 104.
In addition to loss of calcium from your bones, other serious risks include abnormal or very heavy bleeding, liver problems, and allergic reactions such as hives, problems breathing, or not feeling right after the shot. If you have sharp chest pain, cough blood, suddenly have trouble breathing, have a sudden severe headache with vomiting, blindness, trouble talking, weakness, numbness in an arm or leg, get dizzy or faint, or have swelling or severe pain in your leg, you may have a serious blood clot and should call your healthcare provider immediately.
The most common side effects with depo-subQ provera 104 are changes in your monthly period, weight gain of an average of 3 to 4 pounds during the first year, a skin reaction where you got the shot, and headache.
Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
For Patient Information for depo-subQ provera 104, click here.
For Full Prescribing Information for depo-subQ provera 104, click here.

