Can you switch from Depo-Provera Contraceptive Injection 150 to depo-subQ provera 104?
Yes—if your healthcare provider says it’s OK!
Here’s great news if you’re already taking Depo-Provera® Contraceptive Injection 150 (medroxyprogesterone acetate injectable suspension 150 mg). If your healthcare provider says it’s OK, you can switch to depo-subQ provera 104.
As with Depo-Provera Contraceptive Injection 150, you’ll only receive injections every 3 months with depo-subQ provera 104, as prescribed by your healthcare provider. Some reasons to switch include:
- The depo-subQ provera 104 needle is smaller than the one used for
Depo-Provera Contraceptive Injection 150 - It has 31% less hormone than Depo-Provera Contraceptive Injection 150
- depo-subQ provera 104 is 97% to 99.7% effective
- The shot is given under your skin and not into the muscle
INDICATION
depo-subQ provera 104® (medroxyprogesterone acetate injectable suspension 104 mg/0.65 mL) is a drug for birth control. It also helps relieve pain related to endometriosis.
IMPORTANT SAFETY INFORMATION
Using depo-subQ provera 104 may cause you to lose calcium stored in your bones.
The longer you use depo-subQ provera 104, the more calcium you are likely to lose. The lost calcium may not return completely once you stop using depo-subQ
provera 104.
Loss of calcium may cause weak, porous bones (osteoporosis) that could increase the risk that your bones might break, especially after menopause. It is not known whether your risk of developing osteoporosis may be greater if you are a teenager when you start to use depo-subQ provera 104.
You should use depo-subQ provera 104 long-term (for example, more than 2 years) only if other methods of birth control are not right for you.
depo-subQ provera 104 does not protect you from HIV (AIDS) and other diseases spread through sex (STDs).
Do not take depo-subQ provera 104 if you are pregnant or might be pregnant, if you have any unexplained vaginal bleeding, have ever had breast cancer, have ever had serious blood clots, such as blood clots in your legs, lungs, heart, or head, have liver disease, or are allergic to anything in depo-subQ provera 104.
In addition to loss of calcium from your bones, other serious risks include abnormal or very heavy bleeding, liver problems, and allergic reactions such as hives, problems breathing, or not feeling right after the shot. If you have sharp chest pain, cough blood, suddenly have trouble breathing, have a sudden severe headache with vomiting, blindness, trouble talking, weakness, numbness in an arm or leg, get dizzy or faint, or have swelling or severe pain in your leg, you may have a serious blood clot and should call your healthcare provider immediately.
The most common side effects with depo-subQ provera 104 are changes in your monthly period, weight gain of an average of 3 to 4 pounds during the first year, a skin reaction where you got the shot, and headache.
Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
For Patient Information for depo-subQ provera 104, click here.
For Full Prescribing Information for depo-subQ provera 104, click here.

